Bioorganic Chemistry

1 Introduction to Bioorganic Chemistry. - 1. 1 Basic Considerations. - 1. 2 Proximity Effects in Organic Chemistry. - 1. 3 Molecular Adaptation. - 1. 4 Molecular Recognition and the Supramolecular Level. - 2 Bioorganic Chemistry of Amino Acids and Polypeptides. - 2. 1 Chemistry of the Living Cells. - 2. 2 Analogy Between Organic Reactions and Biochemical Transformations. - 2. 3 Chemistry of the Peptide Bond. - 2. 4 Nonribosomal Peptide Bond Formation. - 2. 5 Asymmetric Synthesis of ?-Amino Acids. - 2. 6 Asymmetric Synthesis with Chiral Organometallic Catalysts. - 2. 7 Transition State Analogs. - 2. 8 Antibodies as Enzymes. - 2. 9 Chemical Mutations. - 2. 10 Molecular Recognition and Drug Design. - 3 Bioorganic Chemistry of the Phosphate Groups and Polynucleotides. - 3. 1 Basic Considerations. - 3. 2 Energy Storage. - 3. 3 Hydrolytic Pathways and Pseudorotation. - 3. 4 DNA Intercalants. - 4 Enzyme Chemistry. - 4. 1 Introduction to Catalysis. - 4. 2 Introduction to Enzymes. - 4. 3 Multifunctional Catalysis and Simple Models. - 4. 4 ?-Chymotrypsin. - 4. 5 Other Hydrolytic Enzymes. - 4. 6 Stereoelectronic Control in Hydrolytic Reactions. - 4. 7 Immobilized Enzymes and Enzyme Technology. - 4. 8 Enzymes in Synthetic Organic Chemistry. - 4. 9 Enzyme-Analog-Built Polymers. - 4. 10 Design of Molecular Clefts. - 5 Enzyme Models. - 5. 1 Host-Guest Complexation Chemistry. - 5. 2 New Developments in Crown Ether Chemistry. - 5. 3 Membrane Chemistry and Micelles. - 5. 4 Polymers. - 5. 5 Cyclodextrins. - 5. 6 Enzyme Design Using Steroid Template. - 5. 7 Remote Functionalization Reactions. - 5. 8 Biomimetic Polyene Cyclizations. - 6 Metal Ions. - 6. 1 Metal Ions in Proteins and Biological Molecules. - 6. 2 Carboxypeptidase A and the Role of Zinc. - 6. 3 Hydrolysis of Amino Acid Esters and Amides and Peptides. - 6. 4 Iron and Oxygen Transport. - 6. 5 Copper Ion. - 6. 6Biomodels of Photosynthesis and Energy Transfer. - 6. 7 Cobalt and Vitamin B12 Action. - 7 Coenzyme Chemistry. - 7. 1 Oxidoreduction. - 7. 2 Pyridoxal Phosphate. - 7. 3 Suicide Enzyme Inactivators and Affinity Labels. - 7. 4 Thiamine Pyrophosphate. - 7. 5 Biotin. - 8 Molecular Devices. - 8. 1 Introduction to Self-Organization and Self-Assembly. - 8. 2 General Overview of the Approach. - 8. 3 Specific Examples. - References. Language: English